Category Archives: Anesthetic agents

Episode 218: The REGAIN trial with Mark Neuman

Anesthesia and Critical Care Reviews and Commentary (ACCRAC) Podcast
Anesthesia and Critical Care Reviews and Commentary (ACCRAC) Podcast
Episode 218: The REGAIN trial with Mark Neuman
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In this 218th episode I welcome Dr. Mark Neuman to the show. Dr. Neuman is the PI of the REGAIN trial, published in the NEJM which compared spinal and sedation vs. GA for hip surgery. We discuss the trial and the results.

CME: https://earnc.me/3F73Hw

Show notes by Edison

Random Recs:

Women of Impact in Anesthesiology: Link

Moby Dick: https://en.wikipedia.org/wiki/Moby-Dick

Episode 212: Healthcare’s Impact on Health with Matt Meyer

Anesthesia and Critical Care Reviews and Commentary (ACCRAC) Podcast
Anesthesia and Critical Care Reviews and Commentary (ACCRAC) Podcast
Episode 212: Healthcare's Impact on Health with Matt Meyer
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In this 212th episode I welcome Dr. Matt Meyer to the show to discuss the environmental impact of modern healthcare including the downsides of Desflurane and how we can make personal and system changes to help the environment.

Matt’s email: mmeyer@virginia.edu

CME: https://earnc.me/pcNRAr

Random Recs:

Extraterrestrial: The First Sign of Intelligent Life Beyond Earth: Link

The Office: Link

Episode 197: Environmental Sustainability in Anesthesia with Shreya Aggarwal

Anesthesia and Critical Care Reviews and Commentary (ACCRAC) Podcast
Anesthesia and Critical Care Reviews and Commentary (ACCRAC) Podcast
Episode 197: Environmental Sustainability in Anesthesia with Shreya Aggarwal
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In this 197th episode I welcome Dr. Shreya Aggarwal to the show to discuss the environmental impact of healthcare in general and anesthesiology specifically. We discuss what the impact is and what we can do to mitigate it.

CME: https://earnc.me/8iItl7

Dr. Aggarwal is available at: shreya.aggarwal@northwestern.edu

References:

https://www.asahq.org/about-asa/governance-and-committees/asa-committees/committee-on-equipment-and-facilities/environmental-sustainability

https://www.who.int/teams/environment-climate-change-and-health/air-quality-and-health/health-care-activities

Random Recs:

The White Coat Investor Podcast: https://www.whitecoatinvestor.com/wci-podcast/

How It Happened: https://www.axios.com/podcasts/how-it-happened/

Pizza Dough: https://houseofnasheats.com/web-stories/best-homemade-pizza-crust-recipe/

Episode 193: Keywords Part 15: Pharmacology of Inhaled Anesthetics

Anesthesia and Critical Care Reviews and Commentary (ACCRAC) Podcast
Anesthesia and Critical Care Reviews and Commentary (ACCRAC) Podcast
Episode 193: Keywords Part 15: Pharmacology of Inhaled Anesthetics
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In this 193rd episode I welcome Dr. Gillian Isaac back to the show to discuss another ABA Key Word topic. This time we discuss the pharmacology of inhaled anesthetic agents.

CME: https://earnc.me/hxOv4S

Outline by Dr. Brian Park

References: Barash Clinical Anesthesia 8th edition and Anesthesiahub.com

Random Recs:

Chess.com

A Woman of No Importance

Episode 132: Key Words Part 3: Spinals and Etomidate

Anesthesia and Critical Care Reviews and Commentary (ACCRAC) Podcast
Anesthesia and Critical Care Reviews and Commentary (ACCRAC) Podcast
Episode 132: Key Words Part 3: Spinals and Etomidate
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In this 132nd episode I welcome back Dr. Gillian Isaac to do more ABA keyword review. We review Spinals for the Basic Exam and Etomidate.

CME: https://earnc.me/bT3wiQ

Episode 109: Non-Opioid Adjuncts with Drs. Grant and Bicket part 2

Anesthesia and Critical Care Reviews and Commentary (ACCRAC) Podcast
Anesthesia and Critical Care Reviews and Commentary (ACCRAC) Podcast
Episode 109: Non-Opioid Adjuncts with Drs. Grant and Bicket part 2
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In this 109th episode we pick up where we left off in episode 108 and discuss the intraoperative use of non-opioid adjuncts.

CME: https://earnc.me/k6e6gK

References:

Wick EC, Grant MC and Wu CL. Postoperative Multimodal Analgesia Pain Management With Nonopioid Analgesics and Techniques A Review. JAMA Surg. 2017;152(7):691-697.

Bahr MP, Williams BA. Esmolol, Antinociception, and Its Potential Opioid-Sparing Role in Routine Anesthesia Care. Regional Anesthesia and Pain Medicine. 2018:43(8):815-818.

Grant MC, Ouanes JP, Joshi BL. Perioperative Esmolol and Opioids: Is More Really Less? Regional Anesthesia and Pain Medicine. 2018:43(8):813-814.

IV Lidocaine: https://academic.oup.com/bjaed/article/16/9/292/1743710

Ketamine: https://www.ncbi.nlm.nih.gov/pubmed/29870457

Dextramethorphan: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4755866

Episode 108: Non-opioid adjuncts with Drs. Grant and Bicket Part 1

Anesthesia and Critical Care Reviews and Commentary (ACCRAC) Podcast
Anesthesia and Critical Care Reviews and Commentary (ACCRAC) Podcast
Episode 108: Non-opioid adjuncts with Drs. Grant and Bicket Part 1
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In this 108th episode I welcome Dr. Mike Grant and Dr. Mark Bicket to the show to discuss various non-opioid adjuncts such as esmolol, ketamine, dexmedetomidine, lidocaine, and magnesium, and the role they may play in multimodal anesthesia. In this episode, part 1, we discuss pre and post-op use. Intraop use will be discussed in episode 109.

CME: https://earnc.me/oDhyER

References:

Wick EC, Grant MC and Wu CL. Postoperative Multimodal Analgesia Pain Management With Nonopioid Analgesics and Techniques A Review. JAMA Surg. 2017;152(7):691-697.

Bahr MP, Williams BA. Esmolol, Antinociception, and Its Potential Opioid-Sparing Role in Routine Anesthesia Care. Regional Anesthesia and Pain Medicine. 2018:43(8):815-818.

Grant MC, Ouanes JP, Joshi BL. Perioperative Esmolol and Opioids: Is More Really Less? Regional Anesthesia and Pain Medicine. 2018:43(8):813-814.

IV Lidocaine: https://academic.oup.com/bjaed/article/16/9/292/1743710

Ketamine: https://www.ncbi.nlm.nih.gov/pubmed/29870457

Dextramethorphan: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4755866/ R

Episode 103: Neuromonitoring with Drs. Ritzl and Russo

Anesthesia and Critical Care Reviews and Commentary (ACCRAC) Podcast
Anesthesia and Critical Care Reviews and Commentary (ACCRAC) Podcast
Episode 103: Neuromonitoring with Drs. Ritzl and Russo



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In this 103rd episode I welcome Dr. Eva Ritzl and Dr. Alyson Russo to the show to discuss intraoperative neuromonitoring.

CME: https://earnc.me/k8DsYq

Reference: Solt K and Froman S. Correlating the clinical actions and molecular mechanisms of general anesthetics. Curr Op in Anaes. 2007:20(4);300-306.

Episode 77: Reversal of Neuromuscular Blockade

Anesthesia and Critical Care Reviews and Commentary (ACCRAC) Podcast
Anesthesia and Critical Care Reviews and Commentary (ACCRAC) Podcast
Episode 77: Reversal of Neuromuscular Blockade



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In this episode, episode 77, I discuss reversal of neuromuscular blockade.  This is a follow up to episode 66 in which I covered neuromuscular blockade.

CME: https://earnc.me/An714h

Outline by Brian Park: NMB Reversal Outline

References:

Miller’s Anesthesia 8th Edition. Reversal (Antagonism) of Neuromuscular Blockade. Murphy GS, de Boer HD, Eriksson LI and Miller RD. Chapter 35, 995-1027.e5.

Appiah-Ankam J, Hunter J.  Pharmacology of neuromuscular blocking drugs.  Cont Educ Anaesthesia Critical Care & Pain.  2004;4(1):2-7.

Hristovska AM, Duch P, Allingstrup M, Afshari A. Efficacy and safety of sugammadex versus neostigmine in reversing neuromuscular blockade in adults. Cochrane Database Syst Rev. 2017 Aug 14;8:CD012763.

Keating GM. Sugammadex: A Review of Neuromuscular Blockade Reversal. Drugs. 2016 Jul;76(10):1041-52.

McLean DJ, Diaz-Gil D, Farhan HN, Ladha KS, Kurth T, Eikermann M. Dose-dependent Association between Intermediate-acting Neuromuscular-blocking Agents and Postoperative Respiratory Complications. Anesthesiology. 2015 Jun;122(6):1201-13.

Schaller S, Fink H.  Sugammadex as a reversal agent for neuromuscular block: an evidence-based review.  Core Evidence.  2013;8:57-67.

Episode 66: Neuromuscular Blockers

Anesthesia and Critical Care Reviews and Commentary (ACCRAC) Podcast
Anesthesia and Critical Care Reviews and Commentary (ACCRAC) Podcast
Episode 66: Neuromuscular Blockers



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In this episode, episode 66, I go through an overview of neuromuscular blockers including how they work, how to use them, and what their adverse effects are.  Happy New Year!

CME: https://earnc.me/9GRFyG

The dose of glycopyrrolate should be 0.01 to 0.015mg/kg, not 0.1 to 0.15.

Outline by Brian Park: Outline

References:

Miller’s Anesthesia 7th edition: Chapter 29: Pharmacology of Muscle Relaxants and Their Antagonists. Naguib M and Lien C.

Rocuronium vs succinylcholine for rapid sequence induction intubation. https://www.ncbi.nlm.nih.gov/pubmed/26512948

Neuromuscular blockade: what was, is and will be: https://www.ncbi.nlm.nih.gov/pubmed/25622380

Reversal of neuromuscular block: https://www.ncbi.nlm.nih.gov/pubmed/19468024