Category Archives: Pharmacology

Episode 46: Obstetric Pharmacology and Fetal Assessment with Mike Hofkamp

Anesthesia and Critical Care Reviews and Commentary (ACCRAC) Podcast
Anesthesia and Critical Care Reviews and Commentary (ACCRAC) Podcast
Episode 46: Obstetric Pharmacology and Fetal Assessment with Mike Hofkamp
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In this episode, episode 46, I welcome back Dr. Mike Hofkamp to discuss obstetric pharmacology and fetal assessment.

CME: https://earnc.me/xnT8gE

Outline by Brian Park: Outline

Episode 42: Post-op Nausea and Vomiting (PONV)

Anesthesia and Critical Care Reviews and Commentary (ACCRAC) Podcast
Anesthesia and Critical Care Reviews and Commentary (ACCRAC) Podcast
Episode 42: Post-op Nausea and Vomiting (PONV)
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In this episode, episode 42, I discuss Post-op Nausea and Vomiting (PONV).  I discuss risk factors, complications, treatment and prevention and side effects.

CME: https://earnc.me/31KodT

Outline by April Liu: Outline

UPDATE April, 2018: In this episode I mention that the evidence is not good for Midazolam in preventing PONV.  However, a good friend and colleague, Dr. Michael Grant, did a nice meta-analysis of available trials which concluded that it actually does work fairly well.  Check out his study:

Grant MC, Kim J, Page AJ, et al. The Effect of Intravenous Midazolam on Postoperative Nausea and Vomiting: A Meta-Analysis. Anesthesia & Analgesia: 2016:122(3); 656–663.

Episode 41: Local Anesthetics

Anesthesia and Critical Care Reviews and Commentary (ACCRAC) Podcast
Anesthesia and Critical Care Reviews and Commentary (ACCRAC) Podcast
Episode 41: Local Anesthetics
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In this episode, episode 41, I review local anesthetics including the mechanism of action, commonly used agents, pharmacodynamics and kinetics, toxicity and treatment, and common blocks.

CME: https://earnc.me/rbqGL8

Outline by April Liu: Outline

Episode 30: Management of anticoagulation for non-valvular a-fib

Anesthesia and Critical Care Reviews and Commentary (ACCRAC) Podcast
Anesthesia and Critical Care Reviews and Commentary (ACCRAC) Podcast
Episode 30: Management of anticoagulation for non-valvular a-fib
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In this episode, episode 30, I discuss the new American College of Cardiology Guidelines for the periprocedural management of anticoagulation for patients with non-valvular atrial fibrillation.  This includes whether to stop, when to stop, whether to bridge, how to bridge, and how and when to restart.

CME: https://earnc.me/522vst

Outline by Brian Park: AC for Afib Outline

Episode 26: Sugammadex with Dr. Amit Prabhakar

Anesthesia and Critical Care Reviews and Commentary (ACCRAC) Podcast
Anesthesia and Critical Care Reviews and Commentary (ACCRAC) Podcast
Episode 26: Sugammadex with Dr. Amit Prabhakar
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In this episode I welcome Dr. Amit Prabhakar, one of our critical care fellows, to the show to discuss Sugammadex, a relatively recently approved (in the USA) reversal agent for Rocuronium and Vecuronium.

CME: https://earnc.me/h9cIdh

Outline by Brian Park: Sugammadex outline

Episode 24: The Evils of Sodium Bicarbonate

Anesthesia and Critical Care Reviews and Commentary (ACCRAC) Podcast
Anesthesia and Critical Care Reviews and Commentary (ACCRAC) Podcast
Episode 24: The Evils of Sodium Bicarbonate
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In this episode I first suggest you take a look at the recently published (ahead of print) VANCS study on the use of vasopressin as a sole agent in the treatment of vasoplegic shock.  Then I review the reasons never to use sodium bicarbonate in lactic acidosis.

CME: https://earnc.me/3CX3ha

The Vancs study: https://www.ncbi.nlm.nih.gov/pubmed/27841822

The two articles I recommend on bicarb:

Forsythe: https://www.ncbi.nlm.nih.gov/pubmed/10631227

Sabatini: https://www.ncbi.nlm.nih.gov/pubmed/18322160

Outline by Brian Park: Outline

Episode 19: Vasoactive medications

Anesthesia and Critical Care Reviews and Commentary (ACCRAC) Podcast
Anesthesia and Critical Care Reviews and Commentary (ACCRAC) Podcast
Episode 19: Vasoactive medications
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In this episode I review the receptors that vasoactive drugs act on.  I then review the main vasoactive medications used in the OR and the ICU to treat acute hypotension and the ones used to treat acute hypertension.

CME: https://cmefy.com/moment?id=3VcC8Y8

Outline by April Liu: Outline

Episode 14: Opioids part 2

Anesthesia and Critical Care Reviews and Commentary (ACCRAC) Podcast
Anesthesia and Critical Care Reviews and Commentary (ACCRAC) Podcast
Episode 14: Opioids part 2
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This is the second of two episodes about opioid medications.  In this episode I cover the pharmacokinetics and pharmacodynamics of opioids, some of the common uses for these medications, mixed agonist-antagonist compounds, opioid antagonists, and opioid interaction with other medications.

CME: https://cmefy.com/moment?id=kNv6n0N

Slides to go along with this episode are here: Opioids part 2

Episode 13: Opioids part 1

Anesthesia and Critical Care Reviews and Commentary (ACCRAC) Podcast
Anesthesia and Critical Care Reviews and Commentary (ACCRAC) Podcast
Episode 13: Opioids part 1
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This is the first of a 2 part series on opioid medications.  In this first episode I will talk about how opioids are categorized and their effects on the different body systems.  In the next episode I will discuss their pharmacokinetics and pharmacodynamics as well as their various uses and some details on mixed agonist/antagonists.

CME: https://cmefy.com/moment?id=xPdz_TY

Slides to go along with this episode are here: Opioids part 1

PLEASE NOTE: Around minute 12 I say that auditory evoked potentials are the most sensitive to anesthetics.  This is incorrect.  I should have said visual evoked potentials.  Thanks to Howard Zee for catching that!

Episode 10: IV Induction Agents

Anesthesia and Critical Care Reviews and Commentary (ACCRAC) Podcast
Anesthesia and Critical Care Reviews and Commentary (ACCRAC) Podcast
Episode 10: IV Induction Agents
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In this episode I review the common IV agents used in anesthesia excluding opioids.  I cover Propofol, Barbiturates, Benzodiazepines, Ketamine, Etomidate and Dexmedetomidine.

CME: https://cmefy.com/moment?id=txf7gHH

NOTE: There is an error in the audio recording regarding the dosing units for dexmedetomidine.  I say on the podcast that the dosing units are mcg/kg/min which is INCORRECT.  The correct dosing units are mcg/kg/HOUR.  I have corrected this in the accompanying slides. Thanks to Melanie Browder for picking this up!

Good luck to the recent graduates taking their written board exam on July 29th!

Slides to go along with the podcast are here: IV induction agents slides